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For more information on the possible side effects of methadone, or tips on how to deal with a troubling side effect, talk with your doctor or pharmacist.
Published animal data have reported increased neonatal mortality rein the offspring of male rodents that were treated with methadone prior to mating. In these studies, the female rodents were not treated with methadone, indicating paternally-mediated developmental toxicity. Specifically, methadone administered to the male Kollegium prior to mating with methadone-naive females resulted hinein decreased weight gain in progeny after weaning. The male progeny demonstrated reduced thymus weights, whereas the female progeny demonstrated increased adrenal weights. Further, behavioral testing of these male and female progeny revealed significant differences hinein behavioral tests compared to control animals, suggesting that paternal methadone exposure can produce physiological and behavioral changes rein progeny in this model. Other animal studies have reported that perinatal exposure to opioids including methadone alters neuronal development and behavior rein the offspring. Perinatal methadone exposure hinein rats has been linked to alterations in learning ability, Triebwerk activity, thermal regulation, nociceptive responses and sensitivity to drugs.
This growth deficit does not appear to persist into later childhood. However, children born to women treated with methadone during pregnancy have been shown to demonstrate mild but persistent deficits hinein performance on psychometric and behavioral tests.
Methadone should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
The total daily dose, potency and specific characteristics of the opioid the patient had been taking previously, if any;
Patients developing QT prolongation while on methadone treatment should Beryllium evaluated for the presence of modifiable risk factors, such as concomitant medications with cardiac effects, drugs which might cause electrolyte abnormalities, and drugs which might act as inhibitors of methadone metabolism. For use of methadone to treat pain, the risk of QT prolongation and development of dysrhythmias should Beryllium weighed against the benefit of adequate pain management and the availability of alternative therapies.
If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:
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Do not take any medicine while using methadone hydrochloride tablets until you have first talked to your doctor or pharmacist. They will be able to tell you if it is safe to take other medicines while you are using methadone hydrochloride tablets.
Methadone oral tablet is used to treat pain. It’s also used for detoxification or maintenance treatment of an opioid drug addiction.
Methadone is a prescription drug. It’s an opioid, which makes it a controlled substance. This means this drug has a risk of misuse and may cause dependence.
For people with seizures: This drug may cause more seizures rein people with epilepsy. If your seizure control gets worse while taking this drug, call your doctor.
Urine acidification has been shown to increase renal elimination of methadone. Forced diuresis, peritoneal dialysis, hemodialysis, or charcoal hemoperfusion have not been established as beneficial for increasing the elimination of methadone or its metabolites.
However, the risk is highest when you first Keimzelle taking the drug and after a dosage increase. Your risk may also Beryllium higher if you’Bezeichnung für eine antwort im email-verkehr older or already have breathing or lung problems.